Iten Mamdouh Fawzy Abdelmotaleb

17/10/2023

https://pubs.rsc.org/en/content/articlelanding/2023/ma/d3ma00521f

Iten Mamdouh Fawzy Abdelmotaleb

06/10/2023

https://pubs.acs.org/doi/10.1021/acsomega.3c02991

Iten Mamdouh Fawzy Abdelmotaleb

15/09/2023

https://pubs.rsc.org/en/content/articlehtml/2023/na/d3na00368j

Iten Mamdouh Fawzy Abdelmotaleb

Singab, Abdel Nasser B.; Al-Sayed, Eman; Elissawy, Ahmed; M. Mostafa, Nada M.

02/08/2023

https://fungalbiolbiotech.biomedcentral.com/articles/10.1186/s40694-023-00161-2

Iten Mamdouh Fawzy Abdelmotaleb

17/06/2023

https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.202300200

Iten Mamdouh Fawzy Abdelmotaleb

31/05/2023

https://www.frontiersin.org/articles/10.3389/fphys.2023.1172684/full

Iten Mamdouh Fawzy Abdelmotaleb

17/05/2023

https://pubs.acs.org/doi/full/10.1021/acsomega.2c08295

Iten Mamdouh Fawzy Abdelmotaleb

16/05/2023

https://pubs.rsc.org/en/content/articlehtml/2023/ra/d3ra02875e

Iten Mamdouh Fawzy Abdelmotaleb

Eman M Azmy, Ibrahim F Nassar, Mohamed Hagras, Maghawry Hegazy, Mahmoud Mohamed Mokhtar, Amr Mohamed Yehia, Walaa H Lashin

26/04/2023

https://www.future-science.com/doi/10.4155/fmc-2022-0228

Iten Mamdouh Fawzy Abdelmotaleb

14/03/2023

https://journals.ekb.eg/article_290707_0.html

Iten Mamdouh Fawzy Abdelmotaleb

Abdel Nasser B Singab; Nada M Mostafa; Deepika Bhatia; Pooja Tanaji Suryawanshi; Atul Kabra

21/09/2022

https://www.mdpi.com/1420-3049/27/19/6207

Iten Mamdouh Fawzy Abdelmotaleb

Abdel Nasser B. Singab; Nada M. Mostafa; Eman Al-Sayed; Mokhtar M. Bishr; Ahmed M. Elissawy; Mohamed S. Elnaggar, Yi-Hong Tsai; Fang-Rong Chang

18/05/2022

https://doi.org/10.3390/md20050331

Iten Mamdouh Fawzy Abdelmotaleb

Sherif Ashraf Fahmy,Fortuna Ponte,Emilia Sicilia,Hassan Mohamed El-Said Azzazy

01/07/2021

p-Sulfonatocalix[n]arenes have shown excellent potential for accommodating chemotherapeutic drugs through host–guest complexation and enhancing their anticancer activity. Betaine has been reported to exert an anticancer effect at high concentrations. In order to increase its concentration in cancer cells, we have complexed it with p-SC4, which releases its content in an acidic environment typical of cancer tissue. In this work, a host–guest complex of the chemically stable, natural, and safe active methyl donor (betaine) and p-sulfonatocalix[4]arenes (p-SC4) was designed and characterized using 1H NMR, UV, Job's plot analysis, DFT calculations, and molecular modeling for use in cancer therapeutics. The peak amplitude of the prepared host–guest complexes was linearly proportional to the concentration of betaine in the range of 1.0 × 10−5 M−1 to 2.5 × 10−4 M−1. The reaction stoichiometry between p-SC4 and betaine in the formed complex was 1[thin space (1/6-em)]:[thin space (1/6-em)]1. The stability constant for the complex is 8.9 × 104 M−1 which corresponds to a complexation free energy of −6.74 kcal mol−1. Complexation between betaine and p-SC4 was found to involve the insertion of the trimethylammonium group of betaine into the p-SC4 cavity, as supported by the experimental data. The complex displayed enhanced cytotoxic activities against breast adenocarcinoma cells (MCF-7) and cervical cancer cells (HeLa) compared to free betaine. In conclusion, the host–guest complexation of betaine with p-SC4 increases its concentration in cancer cells, which warrants further investigation for cancer therapy.

Iten Mamdouh Fawzy Abdelmotaleb

Sherif Ashraf Fahmy,Basma M. Saleh,Marwa Y. Issa,Udo Bakowsky,Hassan Mohamed El-Said Azzazy

01/04/2021

This study reports a facile and eco-friendly method for the green synthesis of platinum and palladium nanoparticles (Pt NPs and Pd NPs) using Peganum harmala seed alkaloid fraction. The ζ-potential of the synthesized Pt NPs, Pd NPs and Pt–Pd NPs were −11.2 ± 0.5, −9.7 ±1.2, and −12.7 ± 2.1 mV; respectively. Transmission electron microscopy (TEM) revealed the formation of spherical-shaped nanoparticles with smooth margins. The mean diameters of the synthesized Pt NPs, Pd NPs, and Pt–Pd NPs were determined using TEM analysis and were found to be 20.3 ± 1.9, 22.5 ± 5.7, and 33.5 ± 5.4 nm, respectively. The nanoparticles’ bioreduction was confirmed by ultraviolet–visible (UV–vis) spectroscopy, X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy, and their organic contents were determined by thermal gravimetric analysis (TGA). The Pt–Pd NPs mixture showed more pronounced antioxidant activity of 843.0 ± 60 µM Trolox equivalent (TE)/mg NPs compared to the individual Pt NPs (277.3 ± 13.5 µM TE/mg NPs) and Pd NPs (167.6 ± 4.8 µM TE/mg NPs). Furthermore, the Pt–Pd NPs exhibited significant cytotoxic activities against lung cancer (A549) and breast adenocarcinoma (MCF-7) cells, IC50 of 8.8 and 3.6 µg/mL, respectively; as compared to Pt NPs (IC50 of 10.9 and 6.7 µg/mL, respectively) and Pd NPs (IC50 of 31 and 10.8 µg/mL, respectively and compared to carboplatin (IC50 of 23 and 9.5 µg/mL, respectively). Moreover, molecular docking studies were conducted to explore the possible anticancer and antioxidant mechanisms of the biogenic nanoparticles. Pt NPs, Pd NPs, and their mixture showed inhibitory activity against cysteine proteinase, which supports their high antitumor activity, but moderate antioxidant activity. In conclusion, Pd-Pt NPs mixture prepared using harmala seed alkaloid fraction showed potential as effective antineoplastic agents.

Iten Mamdouh Fawzy Abdelmotaleb

Sherif Ashraf Fahmy ,Fortuna Ponte,Emilia Sicilia ,Udo Bakowsky ,Hassan Mohamed El-Said Azzazy

01/12/2020

P-sulfonatocalix[n]arenes have demonstrated a great potential for encapsulation of therapeutic drugs via host-guest complexation to improve solubility, stability, and bioavailability of encapsulated drugs. In this work, guest-host complexes of a third-generation anticancer drug (oxaliplatin) and p-4-sulfocalix[n]arenes (n = 4 and 6; p-SC4 and p-SC6, respectively) were prepared and investigated, using 1H NMR, UV, Job’s plot analysis, and DFT calculations, for use as cancer therapeutics. The peak amplitude of the prepared host-guest complexes was linearly proportional to the concentration of oxaliplatin in the range of 1.0 × 10−5 M−1 to 2.1 × 10−4 M−1. The reaction stoichiometry between either p-SC4 or p-SC6 and oxaliplatin in the formed complexes was 1:1. The stability constants for the complexes were 5.07 × 104 M−1 and 6.3 × 104 M−1. These correspond to complexation free energy of −6.39 and −6.52 kcal/mol for p-SC4 and p-SC6, respectively. Complexation between oxaliplatin and p-SC4 or p-SC6 was found to involve hydrogen bonds. Both complexes exhibited enhanced biological and high cytotoxic activities against HT-29 colorectal cells and MCF-7 breast adenocarcinoma compared to free oxaliplatin, which warrants further investigation for cancer therapy.

Iten Mamdouh Fawzy Abdelmotaleb

01/06/2018

Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining carbamoylpiperidine analogs containing nipecotic acid scaffold were described. Then, a series of hybrids have been developed by introducing Free radical scavengers. Molecular modeling was performed and structure activity relationships are discussed. Among the series, most potent compounds showed effective AchE inhibitions, high selectivity over butyrylcholinesterase and high radical scavenging activities. On the basis of this work, the ability of analogs containing nipecotic acid scaffold to serve in the design of N-benzyl-piperidine linked multipotent molecules for the treatment of Alzheimer Disease.

Iten Mamdouh Fawzy Abdelmotaleb

Deena S Lasheen, Khaled AM Abouzid

01/05/2018

Aim: Imatinib possesses various mechanisms for combating cancer, making the development of imatinib analogs an attractive target for cancer research. Method: Two series of analogs were designed and synthesized, maintaining the essential pharmacophoric features in imatinib structure. The synthesized compounds were subjected to cell-based antiproliferative assays against nonsmall lung (A549) and colon cancer cell lines. In addition, flow cytometry cell cycle and caspase-3 colorimetric assays were performed. Results: Most compounds showed potent anticancer activity against both cell lines with IC50 = 0.14–5.07 μM. Three compounds demonstrated ability to reinforce cell cycle arrest at G1 stage in a manner similar to imatinib. In addition, they induced apoptosis via activation of caspase-3.

Iten Mamdouh Fawzy Abdelmotaleb

Prof. Dr. Khairia Youssef, Prof. Dr. Hussein I. El-Subbagh

01/07/2017

Iten Mamdouh Fawzy Abdelmotaleb

Khairia M. Youssef, Nasser S.M. Ismail, J. Gullbo, Khaled A.M. Abouzid

01/06/2015

Extensive research conducted within past years revealed that curcumin is a highly pleiotropic molecule that interacts with a diverse range of molecular targets and hence it possess anti-proliferative activities against tumor cells.The great similarities between curcumin analogs and chalcones inspired their testing against tubulin enzyme activity as recent research revealed that chalcones possess cytotoxic activity associated with tubulin inhibition and interference with microtubule formation, which is essential in mitosis and cell replication.

Iten Mamdouh Fawzy Abdelmotaleb

01/01/2013

Molecular Modeling and biology assays for curcumin analogs

Iten Mamdouh Fawzy Abdelmotaleb

01/01/2013

master thesis