Shymaa Hatem Abdelaziim Saleh Emara

26/10/2023

https://www.sciencedirect.com/science/article/pii/S0928098723002427

Shymaa Hatem Abdelaziim Saleh Emara

Elkheshen SA; Kamel AO; Nasr M, Moftah NH; Ragai MH; Elezaby RS

13/04/2022

https://www.tandfonline.com/doi/full/10.1080/10717544.2022.2058652

Shymaa Hatem Abdelaziim Saleh Emara

Shymaa Hatem, Nada M El Hoffy, Reham S Elezaby, Maha Nasr, Amany O Kamel, Seham A Elkheshen

01/08/2020

"Extensive melanin production and accumulation inside the skin may result in a number of disorders, among which is acquired hyperpigmentation, such as melasma. Skin hyperpigmentation is attributed to either the increase in the number of melanocytes or the hyperactivity of melanogenic enzymes. Genetic susceptibility, ultraviolet radiation, hormonal remedies as well as the abnormal release of the α-melanocyte stimulating hormone (α-MSH) represent the provoking factors contributing to such disorder. On the account of their prominent localization in skin-exposed areas, hyperpigmentation may possess cosmetic and psychosocial relevance, and subsequently many efforts have been exerted to help rectify this skin disorder. The current review presents the approaches adopted to treat melasma. It also reviews the active molecules counteracting the melanogenesis process and the diverse nanotechnology-based delivery systems, which showed successful topical delivery of hypopigmenting agents for the treatment of melasma. 1"

Shymaa Hatem Abdelaziim Saleh Emara

Maha Nasr, Noha H. Moftah, Maha H. Ragai, Ahmed S. Geneidi

01/09/2018

The present study aimed to develop vitamin C based nanovesicles (aspasomes) loaded with the antioxidant melatonin, as a novel cosmeceutical to be used for clinical treatment of androgenic alopecia (AGA). Aspasomes were assessed regarding their particle size, charge, drug entrapment, anti-oxidant potential, physical stability, in vitro release, surface morphology, and ex-vivo skin deposition. Clinically, melatonin aspasomes were tested on AGA patients, and assessed by evaluating the degree of improvement through conduction of hair pull test, histometric analysis and dermoscopic evaluation. Results revealed that melatonin aspasomes showed favorable pharmaceutical properties in addition to clinically promising results compared to melatonin solution, manifested by increased hair thickness, density and decreased hair loss, with photographic improvement in most patients. Therefore, melatonin vitamin C-based aspasomes were clinically auspicious in the treatment of AGA, hence, paving the way for their further exploration in other oxidative-dependent dermatological diseases.

Shymaa Hatem Abdelaziim Saleh Emara

Maha Nasr, Noha H Moftah, Maha H Ragai, Ahmed S Genedi

01/08/2018

Shymaa Hatem Abdelaziim Saleh Emara

Geneidi, Ahmed S, Nasr, Maha’

01/08/2018

Antioxidants are among the most important cosmeceuticals, with proven ability of inhibiting cellular damage. The topical skin administration of antioxidants is essential for minimizing skin aging and achieving better skin protection against harmful free radicals. However, their unfavorable physiochemical properties such as chemical instability, excessive hydrophilicity or lipophilicity and others could be a great obstacle against their skin promising effects as well as their delivery to deeper skin layers. These problems could all be remedied through the use of delivery carriers. The present review discusses the various delivery carriers which were proven successful in improving the beneficial effects of antioxidants against skin aging, namely different vesicular systems, lipidic systems, polymeric systems and carbon nanotubes, and their applications in topical antioxidant delivery.