Ola Gamal Hussein Farrag

Mamdouh R. Rezk; Mohamed Abdelkawy; Yasmin Rostom

25/11/2023

https://www.sciencedirect.com/science/article/abs/pii/S0026265X2301336X

Ola Gamal Hussein Farrag

Mamdouh R. Rezk; Mohamed Abdelkawy; Yasmin Rostom

23/07/2023

https://www.sciencedirect.com/science/article/abs/pii/S0731708523003679

Ola Gamal Hussein Farrag

Yasmin Rostom; Mohamed Abdelkawy; Mamdouh R. Rezk

14/06/2023

https://academic.oup.com/chromsci/advance-article-abstract/doi/10.1093/chromsci/bmad042/7197853

Ola Gamal Hussein Farrag

Yasmin Rostom; Mohamed Abdelkawy; Mamdouh R. Rezk

13/04/2023

https://www.sciencedirect.com/science/article/abs/pii/S1386142523004225

Ola Gamal Hussein Farrag

Mohamed Abdelkawy, Mamdouh R. Rezk, Yasmin Rostom

01/04/2023

https://www.sciencedirect.com/science/article/pii/S2211715623001595

Ola Gamal Hussein Farrag

Mohamed Abdelkawy; Mamdouh R. Rezk; Amr M. Mahmoud; Yasmin Rostom

08/03/2023

https://pubs.rsc.org/en/content/articlehtml/2023/ra/d3ra00597f

Ola Gamal Hussein Farrag

Eman S. Elzanfaly; Hala E. Zaazaa; Shimaa A. Atty

11/04/2022

https://iopscience.iop.org/article/10.1149/1945-7111/ac638f/meta

Ola Gamal Hussein Farrag

Aya T. Soudi, Ola G. Hussein, Eman S. Elzanfaly and Hala E. Zaazaa.

01/11/2020

Stability indicating methods are essential to determine the stability of newly developed dosage forms. In this work a simple stability-indicating thin-layer chromatographic (TLC) method was developed and validated to determine Alcaftadine in presence of its main degradation products and preservative benzalkonium chloride in bulk powder and in pharmaceutical formulations. Separation was developed on TLC aluminum plates precoated with silica gel 60F-254 as a stationary phase using chloroform: methanol: ammonia (5:5:0.1, by volume) as a developing system. Densitometric scanning was carried out in the absorbance mode at 282nm. Alcaftadine was subjected to oxidation, acid and alkaline hydrolysis. It was observed that the drug is susceptible to oxidation only. Method validation was carried out according to ICH guidelines and the proposed method was successfully applied to analyze alcaftadine in pharmaceutical dosage form with no interference from dosage form additives or preservatives. Linearity range was found to be 0.50 - 12.00µg/band with a good linear relationship r of 0.9998. Results obtained by the proposed TLC-densitometric method were statistically compared with those obtained by a reported spectrophotometric method and no differences were found.