Marwa Ismail Abdellatif Abou Shabayek

Taghreed A. Majrashi; Tarfah Al-Warhi; Wagdy M. Eldehna; Nada M. Mostafa

16/11/2023

https://www.sciencedirect.com/science/article/pii/S1756464623005005

Marwa Ismail Abdellatif Abou Shabayek

01/09/2023

https://www.eurchembull.com/uploads/paper/927edf1d31b6bc8a8a37a0ee726c6cba.pdf

Marwa Ismail Abdellatif Abou Shabayek

Nancy N. Shahin, Mohamed A. AbdelHafez, Tarek K. Motawai

06/02/2023

https://www.sciencedirect.com/science/article/pii/S0969996123000463

Marwa Ismail Abdellatif Abou Shabayek

Ismail SM, El Boghdady NA, Hamoud HS

01/05/2020

Marwa Ismail Abdellatif Abou Shabayek

El Samaloty NM, Ghait RS, El-Maraghy SA, Rizk SM, El-Sawalhi MM.

01/01/2020

Marwa Ismail Abdellatif Abou Shabayek

01/01/2019

Background Dysregulation of miRNAs has been associated with many clinical conditions, including coronary artery disease (CAD). MiRNAs roles in patients with type 2 diabetes mellitus (T2D) with or without CAD, however, have not been clearly understood. Therefore we studied the expression of miRNAs 342 and 450 and the activity of the NADPH oxidase 4 (NOX‐4), and their association with anthropometric and biochemical parameters of hyperglycaemia and dyslipidaemia. Subjects and Methods Blood was collected from 200 outpatient subjects, divided into four groups of 50 individuals including control, T2D, CAD, and T2D with CAD. CAD was further divided based on CAD with angina, CAD clots, and CAD ischaemia to differentiate the primary cause of CAD. We measured the miRNAs 342 and 450 expression and NOX‐4 activity, in addition to routine parameters. Results The expression of miRNAs 342 and 450 and NOX‐4 activity was significantly different between groups. Furthermore, they presented significant correlations with routine parameters, providing evidence of a potentially beneficial role in stratifying the risk for CAD in patients with T2D. Conclusion The results of this study suggest that the expression of miRNAs 342 and 450 and NOX‐4 activity may help identify those individuals with T2D at high risk for developing CAD as well as the prognosis in those with established CAD.

Marwa Ismail Abdellatif Abou Shabayek

Ola S. Ali, Heba G. Abdelaziz, Dalia O. Makhlouf

01/12/2018

Breast cancer (BC) is the most common malignancy among women; supporting the need for identification of novel prognostic biomarkers, circulating microRNAs (miRNAs) could serve as such in various cancers. The aim of this study was to explore the association between miRNAs 182 and 375 with BC stages and its receptors, based on their expression using real time PCR. Materials and Methods Detailed medical history was taken and blood samples were withdrawn from 80 female subjects divided over the studied groups. Patients ranged in age from 24 to 80 years and were classified as follows: group I included 10 noncancerous postmenopausal control subjects; group II included 32 postmenopausal patients with BC; group III included 10 noncancerous premenopausal control subjects; group IV included 24 premenopausal patients with BC; and group V included 6 patients with benign breast tumors. Results miRNA 182 expression was significantly higher in group II, group IV, and group V (3.36 ± 0.14, 2.52 ± 0.34, and 4.93 ± 0.3,9 respectively); miRNA 375 expression was significantly higher in group II, group IV, and group V (4.41 ± 0.40, 3.12 ± 0.35, and 11.28 ± 2.37, respectively) (P < .05). Both miRNAs were significantly associated with each other and with receptors used for the prognosis of BC even after multiple regression analysis. Conclusion Accordingly, miRNAs 182 and 375 could be potential noninvasive markers used for the follow up of BC patients.

Marwa Ismail Abdellatif Abou Shabayek

Ola M. Sayed, Hanan A. Attaia, Hamdy Abozeed

01/04/2014

Bladder carcinoma is an important worldwide health problem. Both cystoscopy and urine cytology used in detecting bladder cancer suffer from drawbacks where cystoscopy is an invasive method and urine cytology shows low sensitivity in low grade tumors. This study validates easier and less time-consuming techniques to evaluate the value of combined use of angiogenin and clusterin in comparison and combination with voided urine cytology in the detection of bladder cancer patients. This study includes malignant (bladder cancer patients, n = 50), benign (n = 20) and healthy (n = 20) groups. The studied groups were subjected to cystoscopic examination, detection of bilharzial antibodies, urine cytology, and estimation of urinary angiogenin and clusterin by ELISA. The overall sensitivity and specificity were 66 and 75 % for angiogenin, 70 and 82.5 % for clusterin and 46 and 80 % for voided urine cytology. Combined sensitivity of voided urine cytology with the two studied biomarkers was 88 % which is higher than the combined sensitivity of both markers alone (82 %) and that of the cytology with each marker (76 and 80 %) for angiogenin and clusterin respectively. In conclusion, combined use of the cytology with the studied biomarkers can improve the sensitivity for detecting bladder cancer, and may be very useful in monitoring the effectiveness of antiangiogenic and apoptotic therapies in bladder cancer.

Marwa Ismail Abdellatif Abou Shabayek

01/01/2014

A new series of tetrahydro quinazoline and tetrahydro 1H dibenzo diazepine analogs were synthesized and tested for their DHFR inhibition and in vitro antitumor activity. Compound 35 showed a remarkable DHFR inhibitory potency which is twenty fold more active than methotrexate (MTX). Compounds 17 and 23 proved to be fifteen fold more active than the known antitumor 5 FU, with MG MID GI50, TGI and LC50 values of 1.5, 46.8, 93.3 and 1.4, 17.4, 93.3 respectively. Computer modeling studies allowed the identification that methoxy and methyl substituents, the system of the chalcone core, the nitrogen atoms, on the dibenzodiazepine ring as pharmacophoric features essential for activity. These mark points could be used as template model for further future optimization.